
CBD, CBG, CBN Topicals and Gummies: Exploring Efficacy, Bioavailability
In this article we will do a review of the pros and cons of CBD topicals (creams, salves, etc.) versus CBD taken via oral routes, particularly gummies and capsules. Let’s discuss the efficacy and what’s known as the bioavailability with special reference to CBD for back pain which typically is arthritis, muscle strain, sciatica etc.
Introduction: CBD for Chronic Back Pain
Interest in CBD and related Cannabinoids (CBG, CBN) has surged in recent years as a popular wellness remedy for a whole host of ailments and wellness applications. Much has been made of its ability to relax and quell anxiety. There are also more physical applications like reducing inflammation and managing pain, especially chronic pain for conditions such as rheumatoid arthritis and chronic back pain and spinal stenosis. For these conditions users are presented with delivery options: topical or oral ingestion. So which is better? The short answer is that the jury is out but there are studies ongoing and there are strong opinions from either camp. Generally, topical applications are valued for their fast and direct relief and quick onset and the ability to avoid the digestive system. Formats such as gummies however, are praised for their sustained release over time when restful sleep or long term relief is desired.
What is CBD and How Does It Work for Pain?
Technically CBD is as a non-psychoactive cannabinoids compound derived from the Cannabis (or hemp) plant. It is the best known of the cannabinoids after THC which is the cannabinoid that gets you high. The human body has an endocannabinoid system so there is a lot of opportunity for CBD to interact with it and this effect on the ECS is what allows users to regulate pain, mitigate inflammation and influence mood. Both the brain and body have CB1 and CB2 receptors that are affected by CBD.
For back pain especially, there are benefits. These include what is known formally as analgesic (pain relieving) and anxiolytic (anxiety-reducing) properties. The effects have been demonstrated by numerous studies and touted anecdotally for years by users who swear by the benefits. There are of course, users who report little success and others who swear by it. It does seem to vary from person to person. Whether this is a case of receptor affinity is not yet known. So there is a definite reliance on anecdotal evidence and some limited animal research. More large scale human studies are required. To date, there definitely is an indication that CBD administration has a greater effect than placebos.
CBD Creams: Topical Applications for Back Pain
So how do CBD creams work? Are they effective? The way they are applied is that they are applied directly to the skin, targeting localized pain and inflammation.
Bioavailability:
There is low systemic absorption. The CBD interacts primarily with CB2 receptors in the skin.
Effectiveness for Back pain:
It does reduce inflammation and pain in very localized areas.
These preparations are often combined with additional ingredients like menthol, camphor, and sometimes essential oils to soothe and enhance relief.
This is the best route for dealing with arthritis, muscle soreness and sciatica.
Advantages
It is non-invasive and easy to apply as it bypasses the digestive system, so there is minimal risk of side effects. Therefore, there’s less risk of applying an excessive dose. Typical side effects of CBD taken in large amounts orally are avoided.
Disadvantages
Relief is limited to a local area, therefor, it is not effective for widespread persistent pain.
The effects are likely to be more short lived than oral ingestion methods.
CBD Gummies for Back Pain
How Oral CBD Works:
Oral CBD in the form of CBD Gummies is typically absorbed through the digestive system, metabolized by the liver and it is then distributed throughout the system. The exception is with sublingual drops. Sublingual administration refers to placing a drug under the tongue. This permits sublingually applied CBD to be absorbed directly into the bloodstream rapidly due to the extremely vascular area under the tongue.
The bioavailability of ingested CBD is fairly low, being only about (10-20%) as a result of first-pass metabolism. It is enhanced when taken with high fat meals (cheat day!).
Efficacy for Back Pain:
This route of oral ingestion provides full body relief and has the benefit of addressing both pain and anxiety. This is a particularly good benefit as there is an interaction between anxiety and pain. Onset is slower, (about 30-120 minutes) but the effect lasts longer.
This method is helpful for chronic conditions like spinal stenosis or pervasive inflammation.
Advantages:
Convenient and discreet administration.
Longer lasting effects than topical application.
Disadvantages: Onset is delayed by digestion.
There is more potential for digestive discomfort and interactions with other medications.
The Role of Anxiety in Chronic Back Pain
There is a definite connection between chronic pain and anxiety. There is a psychosomatic effect. Pain creates anxiety and anxiety worsens pain perception. Cannabinoids like CBD and CBG (Cannabigerol) are particularly helpful because they can address both pain and anxiety as well as inflammation. Cannabinoids modulate the body’s ECS. Oral CBD (gummies and oil drops) may be more effective for addressing anxiety related pain than topical creams.
Side Effects, Cautions, and Drawbacks
It is always important to be mindful of the common side effects that can occur in some people with moderate or high doses. These are specific to orally ingested cannabinoids.
Common Side Effects:
– Nausea, diarrhea, headaches (more common with oral CBD).
– Drowsiness or dry mouth.
Drug Interactions:
– CBD can interact with blood thinners, antidepressants, and other medications.
As always, you should consult your physician before embarking on a course of treatment with CBD.
Quality Concerns:
– Lack of regulation in the CBD market. It is important to go with an established and reputable brand.
– Purity and Satisfaction Guarantees are always a good idea, as is third-party testing and certificates of analysis (COAs).
– Legal Status: CBD is federally legal if derived from hemp (<0.3% THC), but laws vary.
Mellow CBD Topicals: Product Line Overview
Mellow offers a wide range of oils, tinctures, creams and other topical CBD products in formulations that include CBD, CBG, and CBN
Check our range of Full and Broad Spectrum CBD Oils.
Mellow also offers a range of gummies in delicious flavours and doses to suit your needs and tastes.
Summary
Creams or Gummies: Which is Better for Back Pain?
Topical Creams: Best for localized pain, quick relief, and minimal side effects.
Oral Gummies/Oils: Best for systemic relief, addressing both pain and anxiety.
Personal Preference: Choose based on the type of pain (localized vs. widespread) and desired onset/duration of effects.
As always, Start with a low dose, consult a healthcare provider, and consider combining both methods for comprehensive relief. See also our Beginner’s Guide to CBD for starting your wellness journey with cannabinoids
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