CBN Benefits – October 2025 Update
Since our original article in February 2021, CBN (cannabinol) has continued to gain interest in the wellness sphere. CBN for Sleep continues to be an active area of interest. There is now data that confirms CBN has a potential to improve sleep. Research has continued to show positive effects, and consumer interest has trended upwards. Let’s dive into the exciting updates on CBN, with special attention on its role in sleep support and some other compelling benefits!
A Primer on Cannabinoids – CBD, CBG, CBN
CBN (cannabinol) is a cannabinoid that is found in cannabis and hemp. It comes from the oxidization of tetrahydrocannabinolic acid, THCA, the acid version of THC. As THC age, the gradually breaks down into CBN. Essentially, THC oxidizes into CBN. Because it stems directly from THC, this cannabinoid is still slightly psychoactive but nowhere near its predecessor’s strength
Will CBN Get You High?
Yes in larger doses it can. But only in much larger doses. Because it develops directly from THC, this cannabinoid is slightly psychoactive. However, it is much less potent than THC. So if you’re taking small doses for therapeutic use you needn’t worry about getting high. Especially if the reason for taking it is to facilitate sleep, minor changes in concentration or mild psychoactive effects shouldn’t be too much of a deterrent.
This is a good overview of the relationship between cannabinoids from a US based CBD producer (Syracuse.com)
CBN for Sleep: The Science Is Catching Up
CBN’s reputation as a sleep aid has increased since 2021, with new studies and anecdotal evidence fueling its popularity. There are still indications that CBN may be superior to CBD in enhancing sleep. While early research was limited, recent findings continue to illuminate how CBN interacts with the body’s endocannabinoid system to promote relaxation and restful sleep.
CBN has a particular affinity for CB1 receptors which are responsible for the sedative effects ascribed to THC.
2022 Study on Sleep Quality:
A focused study published in 2022 explored CBN’s effects on sleep latency (the time it takes to fall asleep) and sleep duration. Participants who took a CBN-dominant formulation reported falling asleep faster and experiencing fewer nighttime awakenings. This study, though small, has sparked further interest in CBN as a natural sleep aid. The presented study sought to determine the effects of cannabinol (CBN) alone and in combination with cannabidiol (CBD) on sleep quality.
A link to the study is here
The Entourage Effect in Action:
Researchers are increasingly focusing on the synergistic effects of CBN when combined with other cannabinoids like CBD and minor cannabinoids. A 2023 review highlighted that CBN, when paired with CBD and terpenes like myrcene (known for its sedative properties), may enhance sleep quality more effectively than CBN alone. Click here to see the video of Dr Ethan Russo explaining his research into Cannabinoids, particularly the Entourage Effect that has become a popular area of study in the field of medical applications of Cannabis.
Consumer Demand:
Sleep-deprived individuals are driving interest in CBN. Sales of CBN-infused sleep products, including oils, gummies, and capsules, have surged by over 300% since 2021, according to market reports. Users consistently praise Cannabinol for its ability to deliver a calm, drowsy feeling without the grogginess associated with traditional sleep aids. Admittedly this is anecdotal evidence, not clinical, but it does indicate that people are having success in battling insomnia with CBN.
Beyond Sleep: New Discoveries in CBN’s Benefits
While sleep remains CBN’s star application, research has uncovered even more potential uses for this versatile cannabinoid:
Pain and Inflammation:
A 2023 study reinforced CBN’s anti-inflammatory properties, showing promise for conditions like arthritis and chronic pain. When combined with CBD, CBN demonstrated a stronger ability to reduce inflammation and discomfort compared to either cannabinoid alone.
Neuroprotective Potential:
There is some recent research that supports the idea that CBN may play a role in protecting brain health. A 2023 preclinical study found that CBN could help reduce oxidative stress and inflammation in neural cells, potentially offering benefits for neurodegenerative conditions like Alzheimer’s and Parkinson’s.
Appetite Stimulation:
CBN’s ability to stimulate appetite continues to be explored, particularly for patients undergoing chemotherapy or dealing with eating disorders. A 2022 study confirmed that CBN activates hunger-related pathways in the brain, making it a promising option for those struggling with appetite loss.
Why CBN Is Gaining Popularity
CBN’s rise in popularity isn’t just about its potential benefits—it’s also about accessibility and innovation. Since 2021, the market has seen a surge in CBN products tailored to specific needs:
Targeted Formulations:
Companies are now offering CBN products specifically designed for sleep, often combining it with calming herbs like chamomile, valerian root, and melatonin. These blends are becoming a go-to for those seeking a natural alternative to prescription sleep medications.
Improved Extraction Methods:
Advances in extraction technology have made CBN more affordable and widely available. While it’s still more expensive than CBD, prices have dropped significantly, making it accessible to a broader audience.
Consumer Education:
As awareness grows, more people are learning about CBN’s unique properties. Brands are investing in education to help consumers understand how CBN differs from CBD and THC, and how it can fit into their wellness routines. You can also try [Mellow’s CBN Drops with broad spectrum CBD](https://buymellow.com/shop/oils-and-tinctures/mellow-oil-cbn-drops-600mg-with-11-pure-cbd-and-cbn-cannabinol-20mg-of-cannabinoids-per-ml/) and feel the difference quality cannabinoid formulations make for your sleep!
Is CBN Safe? What We Know Now
Safety remains a top priority, and the good news is that CBN continues to show a favorable safety profile. Side effects are mild and rare, with drowsiness and dry mouth being the most commonly reported. However, as with any supplement, it’s essential to consult a healthcare provider before using CBN, especially if you’re pregnant, nursing, or taking other medications. These are standard disclaimers and the side effects typically experienced with Cannabis. ‘Munchies’ and dry mouth are very near universal side effects associated with Cannabis by nearly everyone who is familiar with its effects!
The Future of CBN
The momentum behind CBN shows no signs of slowing down. Researchers are calling for larger, more rigorous clinical trials to fully understand its mechanisms and benefits. In the meantime, consumer enthusiasm and innovative product development are driving CBN into the mainstream.
At Mellow, we’re thrilled to be at the forefront of this cannabinoid revolution. Our CBD + CBN Night Drops continue to help thousands of customers achieve better sleep and relaxation. As the science evolves, we’re committed to bringing you the latest and greatest in cannabinoid wellness.
Final Thoughts
CBN has continued to grow in popularity since 2021, emerging as a powerful tool for sleep, pain relief, and overall wellness. While research is still ongoing, the evidence—and the glowing reviews—speak for themselves. Whether you’re struggling with insomnia or simply looking to enhance your well-being, CBN is a cannabinoid worth exploring.
Stay tuned as we continue to uncover the incredible potential of CBN. Sweet dreams and brighter days are ahead!
References
Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance.
Narayan AJ, Downey LA, Manning B, Hayley AC.
Neurosci Biobehav Rev. 2022 Dec;143:104941. doi:10.1016/j.neubiorev.2022.104941. Epub 2022 Nov 9.PMID: 36370842 Review.
https://pubmed.ncbi.nlm.nih.gov/36370842/
A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality
Sleep Foundation
https://www.sleepfoundation.org/sleep-aids/cbn-for-sleep
Reddit – Discussion of CBN for Sleep
English (Canada) 
Français du Canada